Fig. 3. Label-retaining cells can re-enter cell division.

(A) Cells in chase were incubated with BrdU for seven days and colocalization of EdU and BrdU was checked. The experiment was performed at one week of chase for interstitial cells and at 3.5 weeks of chase for epithelial cells. Colocalization of EdU and BrdU was observed in cells of all lineages. (B) Colocalization of phosphohistone H3 and EdU was investigated at one week (top panel) and 2.5 weeks (bottom panel) of chase. Scale bars: 10 µm.