Table 1.
Baseline Characteristics According to Serum Creatinine Quartiles
| Serum Creatinine Q1 (<8.7) (N = 282) |
Serum Creatinine Q2 (8.7–10.5) (N = 248) |
Serum Creatinine Q3 (10.6–12.4) (N = 233) |
Serum Creatinine Q4 (>12.4) (N=5 237) |
P Value* | |
|---|---|---|---|---|---|
| Serum creatinine (mg/dL) | 7.1 ± 1.2 | 9.6 ± 0.5 | 11.4 ± 0.6 | 14.4 ± 1.9 | |
| BMI (kg/m2) | 25.3 ± 5.9 | 25.6 ± 5.1 | 26.1 ± 5.4 | 25.9 ± 5.3 | .34 |
| Demographics | |||||
| Age (y) | 63 ± 12 | 59 ± 14 | 57 ± 13 | 49 ± 13 | <.001 |
| Male gender | 71% | 62% | 57% | 37% | .01 |
| Black race | 51% | 68% | 74% | 80% | <.001 |
| Dialysis characteristics | |||||
| HEMO high Kt/V group | 60% | 52% | 47% | 35% | <.001 |
| HEMO high-flux group | 51% | 48% | 55% | 47% | .28 |
| Dialysis vintage (y) | 2.6 ± 3.7 | 3.6 ± 4.7 | 3.7 ± 4.2 | 3.7 ± 4.1 | .01 |
| Comorbidity | |||||
| Diabetes | 60% | 51% | 36% | 22% | <.001 |
| Congestive heart failure | 63% | 50% | 42% | 38% | <.001 |
| Arrhythmias and conduction defects | 52% | 42% | 43% | 28% | <.001 |
| Ischemic and other heart disease | 86% | 82% | 77% | 75% | .009 |
| Cerebral and peripheral vascular disease | 62% | 45% | 37% | 27% | <.001 |
| Gastrointestinal disease | 65% | 65% | 57% | 49% | .001 |
| Respiratory disease | 28% | 17% | 19% | 15% | .001 |
| Nonvascular nervous system disease | 61% | 52% | 47% | 35% | <.001 |
| Malignancy | 11% | 10% | 14% | 6% | .03 |
| Laboratory data | |||||
| Log CRP (mg/L) | 3.1 ± 0.8 | 3.0 ± 0.7 | 2.9± 0.7 | 2.8 ± 0.6 | <.001 |
| Serum albumin (g/dL) | 3.4 ± 0.5 | 3.5 ± 0.4 | 3.6 ± 0.4 | 3.8 ± 0.4 | <.001 |
| Serum bicarbonate (mEq/L) | 21.6 ± 4.1 | 21.1 ± 4.1 | 21.3 ± 4.0 | 20.5 ± 4.1 | .02 |
Q, quartile; BMI, body mass index; HEMO, Hemodialysis Study; CRP, C-reactive protein.
*
P values calculated by analysis of variance for continuous variables and Cochran-Mantel-Haenszel tests.