Figure 9. Stimulation with PMA/Ionomycin does not promote increased IFNγ production in influenza-specific CD8+ T cells isolated from the lungs of coinfected animals.

On d8 post virus infection, cells were isolated from the lungs of animals infected with influenza virus or coinfected and cultured in the presence of NP147-155 peptide or PMA/ION. IFNγ production in the CD8+LFA-1hi, tetramer+ population was determined. Data are the average from two independent experiments in which a total of 5 influenza or 8 coinfected mice were individually assessed. ** p<0.01