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. 2014 Dec 9;20:1643–1659.

Table 1. Genes examined, divided into functional categories, with cellular location of the protein encoded by the gene.

Gene symbol Protein name Location
Signaling − Cell surface
ACVRL1
Activin A receptor 2-like 1
Cell surface
FGFR2
FGF receptor 2
Cell surface
NPR3
Atrial natriuretic peptide receptor 3
Cell surface
SDC2
Syndecan 2
Cell surface
TGFBR3
TGFβ receptor III
Cell surface
TRPV4
Transient receptor potential cation channel V4
Cell surface
UNC5B
Netrin receptor UNC5B
Cell surface
EFNA1
Ephrin A1
Cell surface
Signaling − Cytoskeleton related
ANXA1
Annexin A1
Cell surface
ANXA2
Annexin A2
Cell surface
CAPN2
Calpain 2
Cell surface
CAPNS1
Calpain small subunit 1
Cell surface
GJA1
Connexin 43
Cell surface
ACTA2
Smooth muscle actin
Intracellular
NGEF
Neuronal guanine nucleotide exchange factor
Intracellular
Signaling − Transcription regulators
HIF1A
Hypoxia-inducible factor 1α
Intracellular
RARB
Retinoic acid receptor β
Intracellular
RXRB
Retinoid X receptor β
Intracellular
VDR
Vitamin D receptor
Intracellular
Signaling − Secreted
ANGPTL7
Angiopoietin-related protein 7
Extracellular
IGF1
Insulin-like growth factor 1
Extracellular
IGF2
Insulin-like growth factor 2
Extracellular
IL18
Interleukin 18
Extracellular
PENK
Proenkephalin A
Extracellular
TGFB1
Transforming growth factor β1
Extracellular
TGFB2
Transforming growth factor β2
Extracellular
TGFBI
TGFβ-induced protein
Extracellular
Signaling − Matricellular
CTGF
Connective tissue growth factor
Extracellular
CYR61
Protein CYR61
Extracellular
FBLN1
Fibulin 1
Extracellular
NOV
Protein NOV homolog
Extracellular
SPARC
Secreted protein acidic and rich in cysteine
Extracellular
SPP1
Osteopontin
Extracellular
THBS1
Thrombospondin 1
Extracellular
THBS2
Thrombospondin 2
Extracellular
TNC
Tenascin C
Extracellular
WISP1
WNT1 inducible signaling pathway protein 1
Extracellular
MPs / TIMPs
ADAMTS5
ADAM metallopeptidase with thrombospondin motif, 5
Extracellular
MMP2
Matrix metallopeptidase 2
Extracellular
MMP14
Matrix metallopeptidase 14
Cell surface
TIMP1
TIMP metallopeptidase inhibitor 1
Extracellular
TIMP2
TIMP metallopeptidase inhibitor 2
Extracellular
TIMP3 TIMP metallopeptidase inhibitor 3 Extracellular