Figure 5. Voltage-independent suppression of nAChRs in rat SCG neurons.
(A) Current-voltage relationships of nAChRs induced by 100 μM ACh were derived from the ramp stimulation protocol (membrane potentials increased from −70 mV to +30 mV at a rate of 333 mV/s) in the presence (
) or absence (
) of 4.5 μM bilirubin. (B) There was no voltage dependency regarding the effect of 4.5 μM bilirubin on peak nAChRs currents. Each response was normalized to that without bilirubin at each membrane potential from −70 mV to −20 mV. All data points are expressed as means ± SEMs (n = 5).
