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. 2014 Jan 1;522(13):2928–2950. doi: 10.1002/cne.23558

Figure 10.

Figure 10

Müller cells express the cell cycling marker cyclin D1 in P23H rat retinae and ATP-induced photoreceptor degeneration. Sections of retinae from 2-year-old P23H rat model of retinitis pigmentosa (A), saline-treated rat eyes at 6 months (B), ATP-treated rat eyes at 3 months (C: tile scan; D–F: magnification of three areas from C), and ATP-treated rat eyes at 6 months (G: tile scan; H–J: magnification of three areas from G) post-injection were labeled for Müller glial cells (GS, green), cell cycling (cyclin D1, red), and cell nuclei (DAPI, blue). Arrowhead in G indicates RPE cyclin D1 expression. Arrow in I indicates extreme remodeling events of cyclin D1-positive Müller cells displaced into the choroid. RPE, retinal pigment epithelium; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bars = 100 μm.