Table 2.
In the ATP-Treated Eyes There Are Remodeling Events Consistent With the 10 Major Types of Restructuring of the Retina Seen in Retinal Degenerations (Jones et al., 2003)
| Remodeling event | 3 Months | 6 Months | |
|---|---|---|---|
| Neurons | Cell death including ganglion cell loss | − | + |
| Relocation of all types of surviving neurons | − | + | |
| Fragmentation of the inner plexiform layer lamination | − | + | |
| Evolution of new neurites in complex fascicles surrounded by Müller cell processes | − | + | |
| Formation of new synapses throughout the retina | + | + | |
| Müller glia | Migration | + | + |
| Hypertrophic: column formation | + | + | |
| Glial seal at the distal margin of the retina | + | + | |
| Blood vessel | Atrophy and remodelling | + | + |
| RPE | Invasion of RPE into the retina | + | + |
Evidence of the remodeling event is indicated by a plus sign, absence by a minus sign.