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. 2014 Jan 1;522(13):2928–2950. doi: 10.1002/cne.23558

Table 2.

In the ATP-Treated Eyes There Are Remodeling Events Consistent With the 10 Major Types of Restructuring of the Retina Seen in Retinal Degenerations (Jones et al., 2003)

Remodeling event 3 Months 6 Months
Neurons Cell death including ganglion cell loss +
Relocation of all types of surviving neurons +
Fragmentation of the inner plexiform layer lamination +
Evolution of new neurites in complex fascicles surrounded by Müller cell processes +
Formation of new synapses throughout the retina + +
Müller glia Migration + +
Hypertrophic: column formation + +
Glial seal at the distal margin of the retina + +
Blood vessel Atrophy and remodelling + +
RPE Invasion of RPE into the retina + +
1

Evidence of the remodeling event is indicated by a plus sign, absence by a minus sign.