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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Stem Cells. 2013 Jul;31(7):1350–1362. doi: 10.1002/stem.1382

Figure 4.

Figure 4

Sphere-derived colonies resemble progenitors in their gene expression. Microarrays of three independent colonies of SP sphere-derived stem-like cells (SDSC) were compared to monolayer fibroblasts prior to sphere formation, mouse ESC (W9.5) and published results for mesenchymal stem cells (MSC), neural stem cells (NSC) and bone marrow-derived mesenchymal stem cells (BMMSC) (Materials and Methods; Supplemental Methods and Supplemental Fig. 2). A. Heat map showing that the overall pattern of gene expression in sphere-derived stem cell-like colonies is most similar to MSC, but the pattern is clearly distinct from MSC. B. Heat map comparing expression of mesenchymal and epithelial genes. C. Heat map comparing expression of specific markers seen in adult stem cells, MSC, NSC and endothelial progenitors. Note that the sphere-derived stem-like cells are closest to the ESC in expression of these genes. D. Heat map showing lack of Fsp1/S100a4 expression in MSC and BMMSC compared to MEFs.