. 2014 Nov 4;5(12):1313–1317. doi: 10.1021/ml500389m

Table 2. APD334 in Vitro S1P₁ Preclinical Species EC₅₀ Data and Human S1P_1-5 EC₅₀ Values.

preclinical species S1P₁ EC₅₀ cAMP, nM (E_max %)					human S1P_1–5 EC₅₀ β-arrestin, nM (E_max %)
human	mouse	rat	dog	monkey	S1P₁	S1P₂	S1P₃	S1P₄	S1P₅
0.093 (103)	0.44 (95)	0.32 (99)	0.34 (87)	0.32 (95)	6.10 (110)	>10,000	>10,000	147 (63)	24.4 (73)

Table 2. APD334 in Vitro S1P1 Preclinical Species EC50 Data and Human S1P1-5 EC50 Values.