Table 1.
Summary of UTMD in brain tumor therapy studies
|
Reference |
Animal model |
Chemo drug |
MB |
US |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Type | Dose | Type | Dose | Frequency (MHz) | Pressure (MPa) | Pulse length (ms) | PRF (Hz) | Exposure time of each treatment (s) | Treatment days | ||
| Liu et al.
[34] |
Rat xenograft brain glioma |
BCNU |
13.5 mg/kg |
SonoVue® |
2.5 μg/kg |
0.4 |
0.62 |
10 |
1 |
30 |
1 |
| Ting et al.
[35] |
Rat xenograft brain glioma |
BCNU |
- |
BCNU-loaded MBs |
- |
1 |
0.7 |
10 |
5 |
60 s per sonication and repeated twice |
2 |
| Treat et al. [36] | Rat xenograft brain glioma | Dox | 5.67 mg/kg | Definity® | 0.01-0.02 ml/kg | 1.7 | 1.2 | 10 | 1 | 60–120 s per sonication and repeated to cover the tumor | 1 |