Table 2.
Summary of UTMD in liver tumor therapy studies
|
Reference |
Animal model |
Chemo drug |
MB |
US |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Type | Dose | Type | Dose | Frequency (MHz) | Pressure (MPa) | Pulse length (ms) | PRF (Hz) | Exposure time of each treatment (s) | Treatment days | ||
| Kang et al.
[29] |
Rabbit orthotopic liver tumor |
Dox |
2 mg/rat |
Dox-loaded lipid MBs |
4.4-6.4 × 109 MBs/rabbit |
0.3 |
Intensity: 2 W/cm2 |
10 s on |
- |
360 |
3 |
| 10 s off | |||||||||||
| Li et al.
[28] |
Mice xenograft liver tumor |
HCPT |
4 mg/kg |
HCPT-loaded lipid MBs |
1.1 × 109 MBs/mice |
1 |
Intensity: 2 W/cm2 |
10 s on |
- |
3,600 |
7 |
| 10 s off | |||||||||||
| Cochran et al. [37] | Rat xenograft liver tumor | Dox | 167 μg/rat | Dox-loaded polymer MBs | - | 12–5 | MI: 0.40–0.45 | Doppler mode | 1,000 | 1,200 | 1 |