Figure 6.

Correlation between Methylation and Allelic Expression for A/B and XLsα

The allelic expression of A/B transcript (A), but not that of XLsα (B), correlates with the methylation at their DMRs (Pearson r: A/B: 0.8974, p = 0.001; XL: 0.4425, p = not significant). Cell cultures, quantification of DMR methylation, and analysis of allelic transcript expression were performed as described in the Experimental Procedures section. GNAS transcripts are expressed as percent maternal allele ratio, based on the allele of the maternally expressed NESP55 transcript (see Experimental Procedures for details).