Figure 3.

Effect of a single dose of radiation, daily i.p. ascorbate and combined treatment on survival of tumor-bearing C57BL/6 mice. Tumor-bearing C57BL/6 mice were divided into four groups: one group received a single dose of 4.5 Gy to the brain 8 days after tumor implantation, a second group received daily intraperitoneal injections of ascorbate (day 8–45) after implantation, a third group received both treatments, and a fourth control group received no treatment. Animals were sacrificed when they had lost 10% of their weight in 24 h or after neurological symptoms were evident. Results are representative of four experiments (two with 1 g/kg ascorbate and two with 2 g/kg ascorbate).