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. 2014 Dec 15;4:172. doi: 10.3389/fcimb.2014.00172

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Copyright © 2014 Faugaret, Ben Amara, Alingrin, Daumas, Delaby, Lépolard, Raoult, Textoris and Mège.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional responses of granuloma cells. Granuloma cells and PBMCs were analyzed by microarray. (A) The correspondence analysis of the probeset signature revealed that C. burnetii and BCG-induced granulomas were clearly separated from PBMCs. (B) The hierarchical clustering analysis showed specific clusters of upmodulated and downmodulated probes in granuloma cells compared to PBMCs. Gene expression level is color-coded from blue (downregulation) to red (upregulation). (C) The Venn diagram represents the expression of upmodulated and downmodulated probes in C. burnetii and BCG granuloma compared with PBMCs. The numbers in overlapping regions indicate the number of probes commonly modulated in granuloma cells obtained in response to C. burnetii and BCG. The numbers in non-overlapping regions indicate the number of probes specifically modulated in response to C. burnetii or BCG.