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. 2014 Dec 15;4:172. doi: 10.3389/fcimb.2014.00172

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Copyright © 2014 Faugaret, Ben Amara, Alingrin, Daumas, Delaby, Lépolard, Raoult, Textoris and Mège.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genes related to immune response in granuloma cells. (A) The genes that were modulated in granulomas induced by C. burnetii compared with BCG-induced granulomas were manually classified according to functions previously reported in immune response. The pie chart represents the distribution of modulated genes in each biological group. (B) PBMCs were incubated with C. burnetii-coated beads in the presence of CCL2 Ab, CCL5 Ab, and IgG1 or in their absence (Control) and the formation of granulomas was measured. Results were expressed as relative granuloma formation. ^*p < 0.05 for the comparison of conditions with and without antibodies. (C) The expression of EPHB2, EDN1, IFIT1, OAS2, FASLG, and GNLY genes in granuloma cells was confirmed by qRT-PCR. *p < 0.05 for the comparison between C. burnetii and BCG using Mann-Whitney U-test.