Table 1.

Summary characteristics for the BRCA1 and BRCA2 carriers and non-carrier relatives used in the analysis. All individuals used for analysis were of self-reported white European ancestry. All individuals described below were included in the carrier status analysis shown in Table 2. Male participants and females on whom appropriate censoring data were not available were excluded from the weighted Cox regression analyses shown in Tables 3 and 4.

Characteristic		Non-carriers		BRCA1 carriers		BRCA2 carriers
		Unaffected	Affected	Unaffected	Affected	Unaffected	Affected
Total number		1636	52	797	831	791	715
	Males♂	306	6	198	7	189	45
	Females♀	1330	46	599	824	602	670
Age at blood draw
(mean, se)	All	45.9 (0.3)	55.4 (1.5)	42.8 (0.5)	50.5 (0.4)	44.2 (0.4)	53.9 (0.4)
	♀only	44.5 (0.3)	54.1 (1.5)	39.6 (0.4)	50.4 (0.4)	42.6 (0.5)	53.2 (0.4)
Age at censure
(mean, se)	♀only	n/a	n/a	39.0 (0.5)	41.6 (0.4)	42.7 (0.6)	45.3 (0.4)
Relative telomere length
(mean, se)	All	−10.5 (0.1)	−10.1 (0.6)	−10.3 (0.1)	−10.8 (0.1)	−9.7 (0.1)	−10.1 (0.2)
	♀only	−10.6 (0.1)	−10.0 (0.6)	−10.2 (0.2)	−10.8 (0.1)	−9.7 (0.2)	−10.1 (0.2)