Table 2.

Cancer status and quartile of mean telomere length in female BRCA1 and BRCA2 mutation carriers.

Differences in telomere length (by quartile of length) between cancer-affected and unaffected mutation carriers are shown. Associations are presented as Hazard Ratios (HR) with 95% confidence intervals (95%CI). Analyses are adjusted for age, study plate, and relatedness. Weights were generated for this study based on time at risk before age at censoring, affected status and mutation type (BRCA1 or BRCA2).

	Telomere length and cancer status HR (95%CI), P-het
Relative telomere length	BRCA1 mutation carriers 614 affected, 471 unaffected	BRCA2 mutation carriers 499 affected, 459 unaffected
Q1 longest	1.00 ref	1.00 ref
Q2	0.91 (0.67 – 1.25), 0.57	1.26 (0.87 – 1.84), 0.23
Q3	1.27(0.71 –2.28), 0.42	1.89 (0.90 –3.98), 0.09
Q4 shortest	0.85 (0 37 – 1.98), 0.71	1.27 (0.49 –3.34), 0.62
Per quartile	0.96 (0.76 –1.22) P-trend = 0.76	1.17 (0.88 – 1.56) P-trend = 0.27