Figure 7. Replication timing boundaries preserved among tissues are conserved in mice and humans.
a, Depiction of a timing transition region (TTR) between the early and late replication domains. Early and late boundaries are defined as slope changes at either end of TTRs. b, Boundaries conserved between species for matched mouse and human cell types as a function of preservation among mouse cell types. c, Percentage of boundaries conserved between species (bar graph) and overall conservation of boundaries between comparable mouse and human cell types (CH12 versus GM06990, mESC versus hESC, mouse epiblast stem cells (mEpiSC) versus hESC) as a function of preservation among mouse cell types. d, A Venn diagram compares the replication timing boundaries identified in the mouse and human genome.