Table 1.

Distribution of Clinical Factors Over Time

Characteristic	Mean(SD)a
	Baseline	Month 12	P Value	Month 24	P Value	Month 36	P Value
	Total No. of patients	44	40		31		18
Visual acuity, ETDRS score	14.9 (18.3)	14.4 (19.3)	.65	14.1 (17.3)	.57	15.9 (19.6)	.20
Visual field, mean deviation	−24.4 (8.9)	−25.5 (6.6)	.33	−24.9 (7.1)	.82	−23.9 (7.0)	.23
RNFL thickness on OCT, µm	66.2 (23.9)	55.7 (5.9)	.006	55.3 (4.7)	.03	54.8 (4.3)	.23
PERG amplitude, % of normal	40.3 (18.3)	38.8 (19.2)	.99	42.2 (24.7)	.59	33.3 (13.5)	.13
PERG phase, % of normal	106.2 (7.2)	106.6 (8.0)	.64	107.2 (9.4)	.66	103.5 (9.1)	.07
No. of patients with onset ≤12 mo	13	12		9		4
Visual acuity, ETDRS score	23.3 (21.4)	23.2 (28.3)	.78	18.6 (24.6)	.93	21.9 (28.4)	.41
Visual field, mean deviation	−20.6 (10.1)	−24.1 (7.9)	.33	−24.6 (6.0)	.79	−22.9 (5.1)	.26
RNFL thickness on OCT, µm	93.7 (24.2)	60.3 (4.6)	.001	57.9 (4.8)	.003	56.9 (3.9)	.06
PERG amplitude, % of normal	41.3 (17.0)	37.9 (16.6)	.98	37.8 (21.8)	.72	32.8 (18.3)	.79
PERG phase, % of normal	105.5 (5.4)	105.4 (5.2)	.67	106.2 (8.0)	.99	109.1 (7.5)	.32
No. of patients with onset >12 mo	31	28		22		14
Visual acuity, ETDRS score	11.3 (15.9)	10.6 (12.7)	.35	12.2 (13.5)	.17	14.1 (17.4)	.18
Visual field, mean deviation	−26.0 (7.9)	−26.2 (6.0)	.83	−25 (7.6)	.99	−24.3 (7.6)	.62
RNFL thickness on OCT, µm	53.9 (8.8)	53.6 (5.3)	.52	54.1 (4.3)	.25	54.1 (4.4)	.07
PERG amplitude, % of normal	39.9 (19.1)	39.2 (20.5)	.99	43.8 (26.1)	.36	33.4 (12.7)	.11
PERG phase, % of normal	106.5 (7.9)	107.2 (9.1)	.84	107.6 (10.1)	.58	101.9 (9.1)	.02

Abbreviations: ETDRS, Early Treatment Diabetic Retinopathy Study; OCT, optical coherence tomography; PERG, pattern electroretinogram; RNFL, retinal nerve fiber layer

^aData are based on the number of eyes evaluated. P values were determined for comparison of each follow-up visit with baseline by paired t test.