Table 3. Management and Clinical Outcomes among U.S. Military Personnel Injured in Combat (2009-2011) with Wound Cultures with Fungal Growth.
| Wounds with Recurrent Necrosisa (N = 77) | Wounds without Recurrent Necrosis (N = 19) | p-value | |
|---|---|---|---|
| Surgical Debridements, median (IQR) | |||
| Overall OR visits | 15 (9, 18) | 8 (7, 12) | 0.02 |
| IFI Antifungal Treatment Regimen, No. (%) | |||
| Received treatment | 65 (84.4) | 3 (15.8) | <0.01 |
| Systemic Antifungal Agents, No. (%) | <0.01 | ||
| Amphotericin B (liposomal) alone | 5 (6.5) | 1 (5.3) | |
| Voriconazole alone | 4 (5.2) | 0 | |
| Amphotericin B plus Voriconazole | 55 (71.4) | 2 (10.5) | |
| Antifungal Duration, median days (IQR) | |||
| Amphotericin B (liposomal) | 21 (12, 30) | 4 (2, 6) | 0.01 |
| Voriconazole | 17 (9, 26) | 15 (11, 18) | 0.78 |
| Total antifungal treatment | 18 (7, 29) | 4 (3, 14) | 0.18 |
| Hospitalization, median (IQR)b | |||
| Total duration in ICU (days) | 11 (6, 20) | 4 (3, 6) | <0.01 |
| High-level amputationsc, No. (%) | 15 (19.5) | 1 (5.3) | 0.18 |
| Deaths, No. (%) | 6 (7.8) | 0 | 0.60 |
ICU - Intensive Care Unit; IFI – invasive fungal wound infections; IQR - Interquartile Range; OR - Operating Room
a
Patients met IFI case definition4
b
Data are from both Landstuhl Regional Medical Center (Germany) and U.S. military treatment facilities
c
High-level amputations are defined as total hip disarticulation or hemipelvectomy