TABLE 1.
Receptors expressed by NK cells that have been implicated in antiviral responses or in the regulation of adaptive immunity
| Species | NK cell receptor | Natural cellular ligands | Effect on NK cell activity |
|---|---|---|---|
| Human | NKp30 | B7-H6, BAT3 | Activating |
| NKp44 | Heparan sulfate proteoglycan, heparin, proliferating cell nuclear antigen |
Activating | |
| NKp46 | Heparan sulfate proteoglycan, heparin, vimentin |
Activating | |
| CD94/NKG2A | HLA-E | Inhibitory | |
| CD94/NKG2C | HLA-E | Activating | |
| NKG2D | MICA/MICB, ULBP1–6 | Activating | |
| KLRG1 | Cadherins (E,N,R) | Inhibitory | |
| 2B4 | CD48 | Activating or Inhibitory | |
| ILT2 | HLA class 1 | Inhibitory | |
| KIR2DS1 | HLA-C | Activating | |
| KIR2DS2 | ??? | Activating | |
| KIR2DS4 | HLA-C | Activating | |
| KIR3DS | ??? | Activating | |
| KIR2DL2/3 | HLA-C | Inhibitory | |
| KIR3DL1/2 | HLA-A/HLA-B | Inhibitory | |
| DNAM1 | CD155, Nectin-2 | Activating | |
| NTB-A | NTB-A | Activating | |
| CD16 (FcγRIII) | IgG | Activating | |
| Mouse | NKp46 | ??? | Activating |
| NK1.1 (NKR-P1A) | Lectin-like transcript-1 | Inhibitory | |
| NKG2D | RAE-1a, −1b, −1d, −1e, −1g, H60a–c, MULT1 |
Activating | |
| CD94/NKG2A | Qa-1a | Inhibitory | |
| CD94/NKG2C | Qa-1a | Activating | |
| CD94/NKG2E | Qa-1a | Activating | |
| KLRG1 | Cadherins (E,N,R) | Inhibitory | |
| 2B4 | CD48 | Inhibitory or Activating | |
| Ly49D | H-2Dd | Activating | |
| Ly49H | ??? | Activating | |
| Ly49P | ??? | Activating | |
| Ly49A | H-2Dd, H-2Dk | Inhibitory | |
| Ly49I | H-2Dk | Inhibitory | |
| DNAM1 | CD155, Nectin-2 | Activating | |
| CD16 (FcγRIII) | IgG | Activating |