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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Curr Opin Microbiol. 2014 May 28;20:42–48. doi: 10.1016/j.mib.2014.04.004

Figure 2.

Figure 2

Septins are required for proper cell morphology. (a) While wild type S. cerevisiae cells undergo an apical to isotropic growth transition early in budding, temperature sensitive septin mutants skip this Swe1 mediated checkpoint [41]. (b) U. maydis cells in which individual septin genes have been deleted remain viable yet display strong morphology defects that are not restricted to one region of the cell. These defects are alleviated upon growth in media containing sorbitol, suggesting aberrant shapes could be due to cell wall imperfections [30]. (c) In C. albians cdc3Δ, cdc12Δ, and cdc12-6 mutants grow with curved hyphae that are unable to appreciably invade host tissues. Additionally, these mutants form new germ tubes axial to the original, unlike wild type cells in which the site of polarity is random, suggesting a role for septins in establishing or maintaining cell polarity [13,44*]. (d) In U. maydis, Cdc3 is translated on endosomes traveling to growing cell tips [48**]. Are the other septins translated on the same endosomes? Could this be the basis for septin complex formation?