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. 2014 Dec 5;8:2423–2430. doi: 10.2147/DDDT.S71815

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© 2014 Yu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The clinical relevance of RUNX3 was determined in a patient survival analysis using an online database containing the expression of 22,277 genes and 20-year survival information of 3,455 BC patients.

Notes: RUNX3 mRNA high expression was found to be correlated to better OS for all BC patients followed for 20 years (HR 0.79, P=8.8×10⁻⁵) (A). RUNX3 mRNA high expression was not found to be correlated to better OS in ER-positive patients (HR 0.87, P=0.13) (B), but only in ER-negative patients (HR 0.72, P=0.01) (C).

Abbreviations: BC, breast cancer; ER, estrogen receptor; HR, hazard ratio; mRNA, messenger RNA; OS, overall survival.