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. 2014 Mar 12;41(1):123–132. doi: 10.1093/schbul/sbu032

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© The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 4. — Blood oxygenation level dependent (BOLD) response differences in response to 2-back challenge. (A) Combined schizophrenia and healthy control sample. Herpes simplex virus, type 1 (HSV1)⁺ show greater activation compared with HSV-1⁻ subjects in the substantia nigra, the red nucleus, and thalamus. (B) HSV1⁺ schizophrenia subjects show increased activation in bilateral red nucleus and substantia nigra compared with HSV1⁻ schizophrenia subjects. (C) Increased activation in the prefrontal and parietal regions among HSV1⁺ in controls compared with HSV1⁻ controls. (D) HSV1⁺ schizophrenia subjects showed decreased BOLD responses in the anterior cingulate regions compared with HSV1⁺ HC. (E) HSV1⁻ schizophrenia subjects showing increased BOLD responses in bilateral superior temporal gyri. Increased activation in the prefrontal Brodmann areas 9 and 46 showed a trend (corrected P = .06). For a color version, see this figure online.