Fig. 2.

Threshold-free between-group contrast maps for the vACC seed. To further qualitatively characterize the nature of between-group effects, we highlight each pair-wise group comparison for the vACC seed. (a) Direct threshold-free contrast between HCS and BPP groups. Yellow-orange foci mark areas where BPP showed increased vACC coupling relative to HCS, whereas blue foci mark areas where BPP showed decreased coupling relative to HCS. The border on the medial surface highlights regions that survived the 1-way ANOVA (as shown in figure 1). Consistent with the effect size calculations, there was generally decreased medial prefrontal cortex (PFC) connectivity with the vACC seed for the BPP group (dashed box). (b) In contrast, BPW group was associated with increased medial PFC connectivity with the vACC seed relative to HCS, as evident from the effect size estimates (table 2). (c) Direct comparison of BPP vs BPW groups revealed reductions for the vACC seed along the medial PFC surface for the BPP group relative to the BPW group. Collectively, these results support the hypothesis that vACC connectivity differs between bipolar groups with and without psychosis history.