Table 2.

Regional [¹⁸F]-FEPPA V_Ts in Gray and White Matter ROIs of Patients With Schizophrenia (SCZ) and Healthy Volunteers (HV)

	Gray Matter ROI	HV (n = 27)		SCZ (n = 16)		Model		Diagnostic Effect		Genetic Effect		Age Effect
		Adjusted Mean	SE	Adjusted Mean	SE	F (3,39)	P	F (1,39)	P	F (1,39)	P	F (1,39)	P
V T	Hippocampus	11.45	2.03	8.03	2.65	1.501	.230	1.045	.313	1.801	.187	0.997	.324
	Medial prefrontal cortex	9.03	0.52	9.69	0.67	5.968	.002	0.602	.442	15.606	<.001	1.012	.321
	Temporal cortex	9.59	0.60	9.78	0.78	5.101	.004	0.037	.847	14.173	.001	0.394	.534
	Dorsolateral prefrontal cortex	9.51	0.57	9.83	0.76	4.521	.008	0.110	.742	11.472	.002	1.120	.296
	Striatum	8.17	0.47	8.38	0.61	6.151	.002	0.075	.786	18.443	<.001	0.307	.583
V T, corrected for partial volume effect	Hippocampus	13.08	2.02	9.19	2.63	1.570	.212	1.374	.249	2.227	.144	0.473	.496
	Medial prefrontal cortex	13.10	0.77	13.76	1.00	5.460	.003	0.274	.604	15.869	<.001	0.057	.813
	Temporal cortex	12.39	0.75	12.24	0.98	5.152	.004	0.014	.907	14.878	<.001	0.034	.854
	Dorsolateral prefrontal cortex	13.90	0.84	13.56	1.10	3.905	.016	0.062	.804	11.397	.002	0.028	.869
	Striatum	8.903	0.54	9.03	0.70	6.900	.001	0.020	.888	20.652	<.001	0.230	.634
	White Matter ROI	HV (n = 27)		SCZ (n = 15)		F (3,38)	P	F (3,38)	P	F (3,38)	P	F (3,38)	P
V T	Corpus callosum	7.05	0.82	6.05	1.10	1.127	.350	0.521	.475	2.071	.158	0.299	.588
	Cingulum	8.60	1.06	7.37	1.43	2.066	.121	0.482	.492	3.414	.072	1.371	.249
	SLF	7.37	0.63	6.52	0.85	1.624	.200	0.641	.428	2.559	.118	0.911	.346
	PLIC	7.57	0.56	7.22	0.74	2.314	.092	1.208	.149	6.406	.016	0.400	.531

Note: Factorial ANOVA comparisons were performed for each ROI to compare differences between diagnostic groups, with genotype (HAB vs MAB) and age added as covariates. White matter data obtained from one subject from the SCZ group was excluded, since no reliable kinetic model fit could be achieved in the white matter ROIs (coefficient of variation [COV] > 50). [¹⁸F]-FEPPA, N-acetyl-N-(2-[¹⁸F]fluoroethoxybenzyl)-2-phenoxy-5-pyridinamine; HAB, high-affinity binder; MAB, mixed-affinity binder; PLIC, posterior limb of the internal capsule; ROI, regions of interest; SLF, superior longitudinal fasciculus. Significant values are provided in bold.