Table 3. Heterocycle Modifications.
LLE is calculated using LogD measured at pH 7.4.
Ki data are an average of at least two independent experiments.
Ratio of wtEGFR Kiapp over EGFR(TMLR) Kiapp.
Ratio of wtEGFR Kiapp over EGFR(TMdel) Kiapp.
LLE is calculated using LogD measured at pH 7.4.
Ki data are an average of at least two independent experiments.
Ratio of wtEGFR Kiapp over EGFR(TMLR) Kiapp.
Ratio of wtEGFR Kiapp over EGFR(TMdel) Kiapp.