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| single
dose PK parametersa |
||||||
|---|---|---|---|---|---|---|
| compd | T1/2 (h) | Tmax (h) | Cmax (μM) | AUClast (μM·h) | VD (L/kg) | Clobs (mL min–1 kg–1) |
| 9 | 3.86 | 4.67 | 1.85 | 22.48 | 3.97 | 30.50 |
| 10 | 2.99 | 3.33 | 1.8 | 19.01 | 3.44 | 35.73 |
Each measurement is an average of three mice that received a single 25 mg/kg dose of test compound at 5 mg/mL suspension in 20% Kolliphor. See Figure S2 for details.
