Scheme 5. Synthesis of Inhibitors 26.
Reagents and conditions: (a) K2CO3, DMF, 40 °C; (b) Pd/C, MeOH, H2; (c) EDC, HOBt, DIEA, CH2Cl2, 25 °C; (d) Pd/C, MeOH, H2; (e) 1-chloro-2-isocyanatobenzene, CH2Cl2, 25 °C.
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