Figure 5.

Measurement of the effect of 30 μM (S)-9b on potentiation of glucose-stimulated insulin secretion in primary mouse islets in the presence of 10 nM 1.^23,24 Islets were isolated from C57BL/6 male mice, size-matched into wells of a 12-well plate, and treated with vehicle, exendin-4, or exendin-4 + (S)-9b at both low (5.6 mM) and high (11 mM) glucose for 60 min. n = 3. Data are represented as mean insulin response ± SEM per 100 islet equivalents and analyzed using 2-way ANOVA followed by Sidak’s multiple comparisons test. **p < 0.01, ****p < 0.0001.