. 2014 Nov 25;57(23):10192–10197. doi: 10.1021/jm501375c

Table 1. Structure and Activities of Analogues 9.

graphic file with name jm-2014-01375c_0008.jpg

entry	R	GLP-1R EC₅₀ (μM)	GLP-1R pEC₅₀^a	GLP-1R max^a (%)
(S)-8	Et	2.4	5.69 ± 0.12	53.4 ± 2.03
(S)-9a	n-Pr	6.5	5.18 ± 0.13	48.4 ± 2.77
(S)-9b	i-Pr	1.3	5.88 ± 0.15	59.2 ± 2.53
(S)-9c	2-OMeBn	12.1	4.92 ± 0.09	68.3 ± 3.31
(S)-9d	n-hexyl	10.3	4.99 ± 0.09	55.7 ± 2.63
(S)-9e	CH₂CH₂Ph	14.1	4.74 ± 0.19	68.5 ± 7.96

GLP-1 pEC₅₀ and GLP-1 max data reported as averages + SEM from our calcium mobilization assay; n = 3.