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Percentage of Chinese hamster lung (CHL) cells with chromosome aberrations induced by rmhTNF-α (*P<0.01). MC: mitomycin C, CPA: Cyclophosphamide. The highest doses of rmhTNF-α, the doses of MC and CPA used in this experiment were 50% LD50 (the median lethal dose) of every reagent against CHL cells. There were no significant differences between rmhTNF-α groups and saline. MC and CPA used as positive controls had over twenty times toxicities than rmhTNF-α and saline.
