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Serum pharmacokinetics parameters of rmhTNF-α (40μg/kg) in rhesus monkey tested with sandwich ELISA.
| t1/2 Kα (hr) |
Tpeak (hr) |
Vd (L/kg) |
Cmax (pg/ml) |
CL (L.hr−1.kg−1) |
AUC (pg.hr/ml) |
|
|---|---|---|---|---|---|---|
| The first animal (f) | 2.35 | 0.99 | 27 | 1119 | 8 | 5082 |
| The second animal (f) |
2.02 | 1.34 | 46 | 744 | 16 | 2536 |
| The third animal (m) |
1.42 | 2.69 | 28 | 575 | 13 | 2967 |
| The fourth animal (m) |
1.90 | 1.84 | 30 | 895 | 11 | 3612 |
| X±s | 1.92±0.39 | 1.72±0.74 | 32.75±8.92 | 833±231 | 12±2.92 | 3549±1113 |
