Table 4.
Metabolism profile of one intramuscular doses of [125I]-rmhTNF-α (10μg/kg) in mice.
| Sample period (post-dose) |
Amount (ng/mouse) |
Urine Accumulated amount (ng/mouse) |
Excretory Rate (%) |
Amount (ng/mouse) |
Feces Accumulated amount (ng/mouse) |
Excretory Rate (%) |
|---|---|---|---|---|---|---|
| 0–2hr | 107.1±6.9 | 107.1±6.9 | 53.55 | 7.1±3.0 | 7.1±3.0 | 3.55 |
| 2–4hr | 35.1±2.1 | 142.2±4.5 | 71.10 | 6.9±1.4 | 14.0±2.2 | 7.00 |
| 4–8hr | 22.8±6.7 | 165.0±5.2 | 82.50 | 2.9±2.2 | 16.9±2.2 | 8.45 |
| 8–12hr | 3.2±1.2 | 168.2±4.2 | 84.10 | 0.7±0.1 | 17.6±1.7 | 8.80 |
| 12–24hr | 5.4±2.6 | 173.6±3.9 | 86.80 | 1.4±0.3 | 19.0±1.4 | 9.50 |