Table 3.
Prognostic factors for change in BCVA including phenotypes and genotypes
| CR | Beta | P-value | |
|---|---|---|---|
| Phenotypes | |||
| Age | 0.002 | 0.065 | 0.442 |
| Sex (male/female) | 0.014 | 0.015 | 0.847 |
| Subtypes (typical AMD/PCV) | −0.011 | −0.015 | 0.875 |
| CNV type (classic/occult) | 0.037 | 0.043 | 0.631 |
| GLD | 6.62×10−5 | 0.221 | 0.012† |
| Pre-PDT BCVA | −0.001 | −0.029 | 0.730 |
| Pre-PDT CRT | 9.37×10−6 | 0.004 | 0.959 |
| PED (presence/absence) | 0.167 | 0.183 | 0.039† |
| Genotypes | |||
| VEGF | |||
| rs2010963 | −0.041 | −0.073 | 0.393 |
| rs699947 | −0.018 | −0.027 | 0.753 |
| PEDF | |||
| rs12948385 | −0.334 | −0.441 | 0.140 |
| rs12150053 | 0.380 | 0.112 | 0.091 |
| rs9913583 | −0.048 | −0.062 | 0.519 |
| rs1136287 | −0.003 | −0.007 | 0.941 |
| CFH | |||
| rs1061170 | −0.011 | −0.010 | 0.907 |
| rs800292 | 0.054 | 0.087 | 0.457 |
| rs1410996 | −0.020 | −0.034 | 0.762 |
| HTRA1 | |||
| rs11200638 | 0.146 | 0.253 | 5.29×10−3† |
Notes: Correlation coefficient squared (R2) =0.235;
†
significant by stepwise multiple regression analyses.
Abbreviations: AMD, age-related macular degeneration; CR, coefficient of regression; Beta, standardized partial regression coefficient; PED, pigment epithelium detachment; GLD, greatest linear dimension; PDT, photodynamic therapy; CRT, central retinal thickness; BCVA, best-corrected visual acuity; CNV, choroidal neovascularization; PCV, polypoidal choroidal vasculopathy; CFH, complement factor H; HTRA1, high temperature requirement A-1; PEDF, pigment epithelium-derived factor; VEGF, vascular endothelial growth factor.