Table 5.
Histological findings in experimental models of orthotopic liver transplantation and hepatic steatosis with ischaemic preconditioning (IPC)
| Authors | Animal | Steatosis model | Steatosis, % | Type of steatosis | Duration of IPC, min | Duration of ischaemia, min (perfusate) | Duration of reperfusion | Results in preconditioned (non-preconditioned) steatotic livers |
|---|---|---|---|---|---|---|---|---|
| Jimenez-Castro et al.36 | Rat | Genetic | 40–60% | Mixed | 5 + 10a | 360 (UW) | 240 min | Hepatic injury score: 1.4 ± 0.2 (3.8 ± 0.1)b |
| Casillas-Ramirez et al.37 | Rat | Genetic | 40–60% | Mixed | 5 + 10a | 360 (UW) | 240 min | Hepatic injury score: 1.4 ± 0.2 (3.8 ± 0.1)b |
| Carrasco-Chaumel et al.38 | Rat | Genetic | 40–60% | Mixed | 5 + 10a | 360 (UW) | 240 min | Grade 3 necrosis: 25 ± 1% (65 ± 1%)b |
| Fernandez et al.39 | Rat | Genetic | 40–60% | Mixed | 5 + 10a | 360 (UW) | 240 min | ↓Severity of necrosis |
a
5 min total ischaemia + 10 min reperfusion.
b
P < 0.05 versus non-preconditioned steatotic livers (results shown as mean ± standard error of the mean).
Mixed, presence of both macrovesicular and microvesicular steatosis; UW, University of Wisconsin solution.