Table 5. Mean pharmacokinetic parameters of Lx2-32c liposome and cremophor-based Lx2-32c in SD rats.

Parameter	Cremophor-based Lx2-32c	Lx2-32c liposome
AUC(0-t) (mg/L *h)	15.16±1.41	23.37±2.71
MRT(0-t) (h)	7.94±0.71	19.52±0.77
Cmax (µg/µl)	1.92±0.63	0.94±0.45
CLz/F (L/h/kg)	2.01±0.72	1.19±0.59
Vz/F (L/kg)	16.63±1.07	20.52±0.91

Data are expressed as mean ± SD (n = 4).

AUC: Area Under Curve; MRT: Mean Retention Time; CLz/F: Clearance; Vz/F: Apparent Volume of Distribution.