Table 2. Predictive accuracy of first trimester maternal plasma C19MC microRNA markers for the diagnosis of gestational hypertension.

miRNA	AUC	ROC curve	Cutoff	Sensitivity	Specificity	PPV	NPV	Positive likelihood ratio	Negative likelihood ratio
	(95% CI)	p-value						(95% CI)	(95% CI)
miR-520h	0.817	0.0002	>3.1986	73.30%	92.90%	84.60%	86.70%	10.27	0.29
	(0.669−0.918)							(2.6−40.4)	(0.1−0.7)
miR-518b	0.786	0.0004	>5.5955	73.30%	85.70%	73.30%	85.70%	5.13	0.31
	(0.634−0.896)							(2.0−13.4)	(0.1−0.7)
miR-516-5p	0.85	<0.0001	>1.2013	80.00%	82.10%	70.60%	88.50%	4.48	0.24
	(0.708−0.940)							(1.9−10.3)	(0.09−0.7)
miR-517*	0.752	0.0021	>3.761	73.30%	71.40%	57.90%	83.30%	2.57	0.37
	(0.597−0.871)							(1.3−5.0)	(0.2−0.9)
miR-520a*	0.688	0.031	>2.2471	80.00%	67.90%	57.10%	86.40%	2.49	0.29
	(0.529−0.820)							(1.4−4.5)	(0.1−0.8)