Table 4. Function and functional relationship analysis of target genes of differentially expressed extracellular C19MC microRNAs in patients developing gestational hypertension in relation to pregnancy.

microRNA	Total no. of predicted target genes/ no. of target genes with relation to pregnancy	Target genes with relation to pregnancy
miR-516-5p	349/53	GYS1, MAPK10, MSRB3, EGLN3, ITGA9, PMP22, CD177, PDGFRA, PSG5, LIN28B, TFCP2L1, PSG9, CHAF1B, IL17RE, PSG6, PSG2, DDAH1, KNG1, NOS1, FUT1, FLT1, UMPS, KCNQ3, SPRY2, PSG11, DAZ1, CHM, OBSL1, WARS, SPAST, SH3BGR, MEOX2, CD1A, PSG3, CCNG1, STC1, CCNA2, CCR2, EGR1, SOCS2, ICOSLG, KCNB1, SLC1A1, SLC9A1, MTHFR , IRAK1, TYRO3, CELF4, ANXA4, MS4A1, ADAMTS14, GRB2, SLC6A2
miR-517*	179/21	RND3, CUL4B, SFRP4, SDHC, MTDH, FUT1, LHCGR, SDC4, FUT9, MBD2, ZCCHC10, CCNG1, DGKE, LMNB2, FAS, SH3BGRL2, CASP10, NFIB, TWIST1, GCLC, PAPPA
miR-518b	42/4	TOLLIP, SLCO4C1, PRDX6, CXADR
miR-520h	509/65	NOX4, VAV3, KLF12, FBN1, JAZF1, CAPN2, TRPC5, ANXA4, LAMP2, HIF1A, RND3, EIF4E, GNA14, PAK2, NR4A2, GBP6, TLR5, GCH1, PHF14, PRCP, SENP1, MYCN, TFAM, CALU, OCLN, CCNB1, EDNRA, SLC41A1, F3, CNR1, ITGAV, SDC2, E2F1, GLRX, CGA, RGS2, ADAMTS5, PRIM2, CDKN1A, PCK1, TGFB2, LIN28B, ABCA1, UNG, AHRR, CDKN2B, SLK, OLR1, NOD2, PKHD1, LRP8, S1PR3, ACP1, BCOR, PAFAH1B2, IRS1, PAH, GRIP1, DMD, GPLD1, NTRK2, FURIN, ANGPT1, TBX1, PTPN1

All the targets were predicted by a bioinformatics tool MirTarget2 using miRDB online database.