Table 4. Enzymatic parameters ( for direct and indirect reactions, , kinetic rate expressions) relating to the new enzymes introduced in the model for lipid metabolism.
Enzyme | EC number | (mM h−1) | (mM) | (mM) | Kinetic rate |
Acetyl-CoA carboxylase | 6.4.1.2 | 3723 | 0.05 (Acetyl-CoA 1) | ||
Fatty-acid synthase | 2.3.1.85 | 19212·10-6 | 0.019 (Malonyl-CoA) | ||
Glycerol kinase | 2.7.1.30 | 762·10−3 | 0.046 (Glycerol) | ||
Glycerol-3-phosphate dehydrogenase | 1.1.1.8 | 357000 | 0.15 (DHAP) 0.01 (NADH) | 0.19 (Glycerol-3P) | |
Acyl-CoA Synthase | 6.2.1.3 | 107.175·10−3 | 0.00278 (Palmytate) | ||
Glycerol-3-phosphate acyltransferase | 2.3.1.15 | 3.876 | 0.46 (Glycerol-3P) 0.0031 (Palmitoyl-CoA) | ||
1-acylglycerol-3-phosphate acyltransferase | 2.3.1.51 | 10.98·10−6 | 0.01630 (Acyl-CoA) | ||
Diacylglycerol acyltransferase | 2.3.1.20 | 6723·10−3 | 0.008 (Oleoyl-CoA) | ||
STG (Synthesis of Triglycerides) | (cumulative) | ||||
Lipoprotein lipase | 3.1.1.34 | 2.261 | 0.053 (VLDL) |
Abbreviations: ATP (Adenosine TriPhosphate); DHAP (dihydroxyacetone phosphate); NADH (Nicotinamide Adenine Dinucleotide Hydrogen); Glycerol-3P (Glycerol-3-Phosphate); FAEP (hEPpatic Fatty Acids); VLDL (Very Low-Density Lipoprotein); TriglycerideEP (hEPpatic Triglyceride).