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. 2014 Dec 15;9(12):e111946. doi: 10.1371/journal.pone.0111946

Table 4. Enzymatic parameters (Inline graphic for direct Inline graphicand indirect Inline graphic reactions, Inline graphic, kinetic rate expressions) relating to the new enzymes introduced in the model for lipid metabolism.

Enzyme EC number Inline graphic (mM h−1) Inline graphic (mM) Inline graphic (mM) Kinetic rate
Acetyl-CoA carboxylase 6.4.1.2 3723 0.05 (Acetyl-CoA 1) Inline graphic
Fatty-acid synthase 2.3.1.85 19212·10-6 0.019 (Malonyl-CoA) Inline graphic
Glycerol kinase 2.7.1.30 762·10−3 0.046 (Glycerol) Inline graphic
Glycerol-3-phosphate dehydrogenase 1.1.1.8 357000 0.15 (DHAP) 0.01 (NADH) 0.19 (Glycerol-3P) Inline graphic
Acyl-CoA Synthase 6.2.1.3 107.175·10−3 0.00278 (Palmytate) Inline graphic
Glycerol-3-phosphate acyltransferase 2.3.1.15 3.876 0.46 (Glycerol-3P) 0.0031 (Palmitoyl-CoA)
1-acylglycerol-3-phosphate acyltransferase 2.3.1.51 10.98·10−6 0.01630 (Acyl-CoA)
Diacylglycerol acyltransferase 2.3.1.20 6723·10−3 0.008 (Oleoyl-CoA)
STG (Synthesis of Triglycerides) (cumulative) Inline graphic
Lipoprotein lipase 3.1.1.34 2.261 0.053 (VLDL) Inline graphic
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Abbreviations: ATP (Adenosine TriPhosphate); DHAP (dihydroxyacetone phosphate); NADH (Nicotinamide Adenine Dinucleotide Hydrogen); Glycerol-3P (Glycerol-3-Phosphate); FAEP (hEPpatic Fatty Acids); VLDL (Very Low-Density Lipoprotein); TriglycerideEP (hEPpatic Triglyceride).