TABLE 1.

Iliac vein corticosteroid levels pre- and post- ACTH infusion

Steroid	Pre ACTH nmoles/L	Post ACTH nmoles/L	P values	Fold Change
Pregnenolone	0.90 ± 0.20	1.64 ± 0.24	0.029	2.28 ± 0.47
17α-Hydroxypregnenolone	0.64 ± 0.16	1.71± 0.33	0.002	3.29 ± 0.67
Progesterone	0.90 ± 0.67	1.02 ± 0.63	NS	0.50 ± 0.20
17α-Hydroxyprogesterone	0.82 ± 0.27	2.08 ± 0.47	< 0.001	4.04 ± 0.87
Deoxycorticosterone	ND	0.41 ± 0.09	0.002	-
Corticosterone	1.17 ± 0.17	16.2 ± 1.72	< 0.001	17.0 ± 3.38
Aldosterone	0.23 ± 0.10	0.64 ± 0.17	0.003	3.76 ± 0.57
11-Deoxycortisol	0.22 ± 0.07	1.54 ± 0.17	< 0.001	13.0 ± 3.04
Cortisol	139.3 ± 21.4	439.0 ± 27.9	< 0.001	3.80 ± 0.72
Cortisone	20.9 ± 2.58	26.6± 1.69	0.029	1.34 ± 0.15

Adrenal vein plasma samples were collected prior to ACTH infusion and 15 minutes after IV administration of 10 IU of ACTH from 9 PA patients (3 male, 6 female). Corticosteroids were quantified by LC-MS/MS. Values are expressed as mean ± SEM The fold change increase following ACTH infusion is shown as the mean fold change ± SEM. ND, not detected.