TABLE 2.

Adrenal vein corticosteroid levels pre- and post- ACTH infusion

Steroid	Pre ACTH nmoles/L	Post ACTH nmoles/L	P values	Fold Change
Pregnenolone	8.37 ± 5.25	560.0 ± 168.5	0.012	300.4 ± 113.3
17α-Hydroxypregnenolone	7.12 ± 3.93	414.9 ± 88.8	0.002	186.6 ± 62.2
Progesterone	0.70 ± 0.33	60.5 ± 14.3	0.003	199.0 ± 68.6
17α-Hydroxyprogesterone	7.54 ± 3.89	423.2 ± 90.9	0.002	137.2 ± 36.1
Deoxycorticosterone	1.09 ± 0.30	68.3 ± 15.6	0.002	82.2 ± 19.2
Corticosterone	31.4 ± 8.14	2550.6 ± 673.9	0.006	124.5 ± 35.9
Aldosterone	3.12 ± 1.07	24.2 ± 5.59	0.002	13.5 ± 4.12
11-Deoxycortisol	9.44 ± 3.86	187.2 ± 40.5	0.002	32.7 ± 7.76
Cortisol	982.9 ± 227.8	17994.6± 4759.8	0.007	23.4 ± 5.55
Cortisone	36.0 ± 3.56	262.6 ± 55.6	0.003	7.58 ± 1.66

Adrenal vein plasma samples were collected prior to ACTH infusion and 15 minutes after IV administration of 10 IU of ACTH from 9 PA patients (3 male, 6 female). Corticosteroids were quantified by LC-MS/MS. Values are expressed as mean ± SEM The fold change increase following ACTH infusion is shown as the mean fold change ± SEM