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. Author manuscript; available in PMC: 2015 Nov 20.
Published in final edited form as: Cell. 2014 Nov 20;159(5):1212–1226. doi: 10.1016/j.cell.2014.10.050

Figure 3. Perturbations of protein interactions by disease and common variants.

Figure 3

Fraction of interactions of the wild-type gene product lost by mutants bearing the disease-associated or common variants (top right, error bars indicate standard error of the proportion). P value, two-sided Fisher’s exact test. Comparison of interaction profile of wild-type CDK4, AANAT, and RAD51D to the interaction profiles of mutant bearing disease or common variants (bottom). Yeast growth phenotypes on SC-Leu-Trp-His+3AT media in quadruplicate experiments are shown.

See also Figure S3 and Table S3.