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. Author manuscript; available in PMC: 2014 Dec 15.
Published in final edited form as: Aging Cell. 2013 Sep 11;12(6):1144–1147. doi: 10.1111/acel.12142

Figure 2. Progressive lipodystrophy and neurological complications in a new mouse model of Type I/II CS.

Figure 2

A. Kaplan Meier analysis of CX mice born to dams fed hard chow pellets (dotted line, n=10) or soft diets as indicated (LFD, n=47; HFD, n=29; chow agar, n=22). Arrow indicates weaning at 4 weeks of age. B. Representative image of CX and control littermates at 14 wks of age. C. Body weights of CX and control mice weaned onto chow pellets at 4 wks or CX mice switched to HFD at 7 wks (arrowhead); n=3/group. D. Body fat percentage of CX and control mice fed HFD or chow pellets over the indicated time period (n=3/group). E. Grip strength of CX and control mice at the indicated age (n=3/genotype/age) as determined by the length of time hanging on a wire. Asterisks indicate significance according to a one-way ANOVA followed by Dunnett's multiple comparison test vs. the 5 week time point within genotype (* p<0.05); between genotype comparisons were significant (p<0.05) at each timepoint by one-way ANOVA and Tukey's multiple comparison test. F. Representative image of 16 wk old CX mouse displaying hind-limb paralysis, lipodystrophy and kyphosis.