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DACT2 inhibits both Wnt/β-catenin and Wnt/c-Jun signaling pathway. A. Results of TCF/LEF luciferase reporter assay. TopFlash: TCF/LEF-responsive reporter; pRL-TK: internal control; WT: wild-type; Mut: mutant. B. p-β-catenin, β-catenin, C-myc and p-c-Jun expression. p-β-catenin: phosphorylated β-catenin; p-c-Jun: phosphorylated c-Jun. Con siRNA: siRNA control; 8# siRNA: DACT2 siRNA #8.
