Table 2.

Univariate Cox regression analysis of the association between miR-199a and the clinicopathological features of patients with osteosarcoma

Clinic-pathologic Characteristics	DFS		OS
	Hazard ratio (95% CI)	P	Hazard ratio (95% CI)	P
Gender
(Male vs Female)	0.448 (0.126-1.592)	0.215	1.039 (0.220-4.869)	0.444
Age
(< 18 years vs ≥ 18 years)	0.359 (0.114-1.133)	0.081	0.328 (0.103-1.039)	0.058
Tumor size
(< 6cm vs ≥ 6cm)	2.263 (0.803-6.374)	0.122	4.362 (1.332-14.286)	0.015
Primary Location1	1.159 (0.638-2.108)	0.628	1.162 (0.657-2.053)	0.606
Surgery type
(Limb sparing vs Amputation)
	1.174 (0.400-3.445)	0.770	1.143 (0.386-3.385)	0.809
Histological type2
	0.967 (0.741-1.262)	0.803	1.006 (0.767-1.320)	0.965
Local recurrence/ Lung metastasis
(Yes vs No)	3.007 (1.233-7.333)	0.017	4.007 (1.513-10.612)	0.024
miR-199a-3p Expression
(Low vs High)	0.374 (0.121-1.154)	0.016	0.740 (0.251-2.179)	0.005

¹Primary location include: Humerus, Radius, Femur, Tibia, Fibula, Others;

²Histological type include: Osteoblastic, Chondroblastic, Fibroblastic, Dilated blood vessels, Others.