Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed molecular pathways for integrin-ERBB2 signaling to stimulate proliferation of thyroid tumor cells in ThrbPV/PV KrasG12D mice. Synergistic oncogenic actions of TRβPV and KrasG12D activate signaling mediated by integrins, ERBB2, and ERK, leading to increased expression of MYC. Elevated MYC stimulates downstream targets such as cyclin D1 to promote aggressive tumor growth in ThrbPV/PV KrasG12D mice.
