Figure 5.

Overexpression of LOX inhibited (A) migration and (B) invasion of HK1 cells. Cells were seeded in serum-free medium in the inserts of Transwell chambers (A) or Matrigel invasion chambers (B). Medium with 10% FBS was added in the lower chambers. After 27 h, cells migrating or invading through the inserts were fixed, stained and counted (at 200× magnification). The migration or invasion of HK1-vector under normoxia was expressed as 100%. Results were depicted as means ± SEM of three independent experiments. The * indicates statistical significant when compared to same cells under normoxia condition. The # indicated statistical significant when compared to vector control during hypoxia conditions. The < indicates statistical significant when compared to vector control during normoxia conditions.