Table 3.

IHC expression for HER family and clinicopathological characters in GISTs with operation only

	Total	%	EGFRs				HER2				HER4
			—	%	+	%	—	%	+	%	—	%	+	%
Age (years)
≤ 50	81	20.0	38	9.4	43	10.6	42	10.4	39	9.6	45	11.1	36	8.9
> 50	324	80.0	139	34.3	185	45.7	153	37.8	171	42.2	162	40.0	162	40.0
Gender
Male	215	53.1	101	24.9	114	28.1	109	26.9	106	26.2	113	27.9	102	25.2
Female	190	46.9	76	18.8	114	28.1	86	21.2	104	25.7	94	23.2	96	23.7
Tumor site
Stomach	238	58.8	111	27.4	127	31.4	126	31.1	112	27.7	128	31.6	110	27.2
Small bowel	129	31.9	45	11.1	84	20.7	44	10.9	85	21.0	55	13.6	74	18.3
Colorectum	19	4.7	14	3.5	5	1.2	15	3.7	4	1.0	11	2.7	8	2.0
Others	19	4.7	7	1.7	12	3.0	10	2.5	9	2.2	13	3.2	6	1.5
Tumor size (cm)
≤ 2.0	36	8.9	23	5.7	13	3.2	27	6.7	9	2.2	26	6.4	10	2.5
2.1-5.0	194	47.9	84	20.7	110	27.2	89	22.0	105	25.9	102	25.2	92	22.7
5.1-10.0	115	28.4	41	10.1	74	18.3	53	13.1	62	15.3	52	12.8	63	15.6
> 10.0	60	14.8	29	7.2	31	7.7	26	6.4	34	8.4	27	6.7	33	8.1
Mitoses per 50 HPFs
≤ 5	327	80.7	145	35.8	182	44.9	162	40.0	165	40.7	174	43.0	153	37.8
6-10	43	10.6	17	4.2	26	6.4	17	4.2	26	6.4	15	3.7	28	6.9
> 10	35	8.6	15	3.7	20	4.9	16	4.0	19	4.7	18	4.4	17	4.2
Modified NIH criteria
Very low risk	32	7.9	21	5.2	11	2.7	26	6.4	6	1.5	25	6.2	7	1.7
Low risk	187	46.2	83	20.5	104	25.7	85	21.0	102	25.2	98	24.2	89	22.0
Intermediate risk	62	15.3	24	5.9	38	9.4	34	8.4	28	6.9	31	7.7	31	7.7
High risk	124	30.6	49	12.1	75	18.5	50	12.3	74	18.3	53	13.1	71	17.5
Total	405	100.0	177	43.7	228	56.3	195	48.1	210	51.9	207	51.1	198	48.9