Table 5.
Univariate & multivariate cox proportional hazards model to predict factors associated with RFS in GISTs with operation only
| Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
|
|
|
|||
| Hazard Ratio (95% Cl) | P value | Hazard Ratio (95% Cl) | P value | |
| Total | ||||
| Age | 1.414 (0.692-2.887) | 0.342 | 0.905 (0.422-1.943) | 0.799 |
| Gender | 0.413 (0.231-0.738) | 0.003** | 0.523 (0.287-0.954) | 0.034* |
| Tumor site | 1.728 (1.309-2.281) | < 0.001** | 1.392 (1.034-1.875) | 0.029* |
| Tumor size | 4.280 (2.990-6.127) | < 0.001** | 2.812 (1.900-4.161) | < 0.001** |
| Mitosis count | 4.251 (3.180-5.681) | < 0.001** | 2.762 (1.980-3.850) | < 0.001** |
| EGFR | 0.703 (0.415-1.188) | 0.188 | 0.648 (0.360-1.166) | 0.148 |
| HER2 | 1.063 (0.628-1.799) | 0.819 | 0.949 (0.515-1.749) | 0.867 |
| HER4 | 1.870 (1.088-3.213) | 0.023* | 2.370 (1.269-4.423) | 0.007** |
| Stomach sub-group | ||||
| Age | 1.507 (0.348-6.527) | 0.583 | 1.099 (0.229-5.273) | 0.906 |
| Gender | 0.339 (0.129-0.892) | 0.028* | 0.942 (0.313-2.838) | 0.915 |
| Tumor size | 4.452 (2.407-8.235) | < 0.001** | 2.225 (1.101-4.499) | 0.026* |
| Mitosis count | 7.181 (4.207-12.256) | < 0.001** | 6.337 (3.302-12.159) | < 0.001** |
| EGFR | 0.745 (0.302-1.836) | 0.522 | 0.730 (0.245-2.174) | 0.572 |
| HER2 | 1.298 (0.527-3.198) | 0.571 | 1.453 (0.498-4.242) | 0.494 |
| HER4 | 3.745 (1.348-10.410) | 0.011* | 5.207 (1.567-17.297) | 0.007** |
| Small bowel sub-group | ||||
| Age | 2.114 (0.803-5.565) | 0.129 | 0.743 (0.228-2.419) | 0.622 |
| Gender | 0.651 (0.287-1.480) | 0.306 | 0.508 (0.209-1.232) | 0.134 |
| Tumor size | 3.847 (2.325-6.365) | < 0.001** | 3.141 (1.687-5.847) | < 0.001** |
| Mitosis count | 3.452 (2.234-5.334) | < 0.001** | 2.282 (1.359-3.832) | 0.002** |
| EGFR | 0.490 (0.232-1.032) | 0.060 | 0.539 (0.232-1.249) | 0.149 |
| HER2 | 0.653 (0.308-1.382) | 0.265 | 1.003 (0.397-2.535) | 0.995 |
| HER4 | 0.977 (0.461-2.067) | 0.951 | 1.217 (0.485-3.053) | 0.675 |
*
P < 0.05;
**
P < 0.01.